| Product Name | Acetyl Tetrapeptide-5 |
| Synonyms | Eyeseryl, Ac-βAla-His-Ser-His, N-Acetyl-β-alanyl-L-histidyl-L-seryl-L-histidine |
| CAS Number | 820959-17-9 |
| Sequence (3-Letter) | Ac-βAla-His-Ser-His-OH |
| Sequence (1-Letter) | Ac-βAla-HSH-OH |
| Molecular Formula | C₂₀H₂₈N₈O₇ |
| Molecular Weight | 492.5 |
| Category | Cosmetic Peptide |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Free acid / acetate (TFA-free available on request) |
| Peptide Content | ≥90% |
| Solubility | Water-soluble; also soluble in DMSO |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg |
| QC Documentation | COA, HPLC, MS (included with every order) |
| Usage | For cosmetic formulation and research use only. Supplied as a raw material; finished-product efficacy and safety claims are the formulator's responsibility. Not a drug; not for direct use without formulation. |
Acetyl Tetrapeptide-5 is a synthetic four-amino-acid cosmetic peptide, sequence Ac-βAla-His-Ser-His (CAS 820959-17-9), best known under the trade name Eyeseryl. The N-terminal acetyl group improves stability and skin penetration. It is supplied as a white powder for eye-care formulations and research.
It is an anti-puffiness, anti-eye-bag ingredient used to reduce the look of under-eye puffiness, eye bags, and dark circles, and to support firmness in the eye area. Suppliers describe it as an anti-edema eye peptide. Any efficacy claim on a finished product is the formulator's responsibility.
Puffy eyes are largely caused by fluid building up in the under-eye area. Acetyl Tetrapeptide-5 is reported to reduce vascular permeability and support lymphatic drainage, and to inhibit glycation of skin proteins, which together help limit fluid accumulation and the eye bags and dark circles that follow. This is a local cosmetic effect at low use levels, not a systemic or medical treatment.
It is used at very low levels, usually a fraction of a percent of the finished formula, and it is water-soluble and easy to incorporate into eye serums, gels, and creams. We can advise on exact use levels for your product.
Yes. We manufacture Acetyl Tetrapeptide-5 in-house and supply from milligrams to kilograms, with COA, HPLC, and MS included. Contact us with your required purity and quantity for a quote.
Acetyl Tetrapeptide-5 is a synthetic peptide used in eye-care cosmetics to reduce the look of under-eye puffiness, eye bags, and dark circles. It is marketed under the trade name Eyeseryl and is one of the most widely used peptides for the periorbital area.
The peptide has the sequence Ac-βAla-His-Ser-His, four residues built on beta-alanine, histidine, serine, and histidine, with an acetyl group on the N-terminus. Its CAS number is 820959-17-9, its molecular formula is C20H28N8O7, and its molecular weight is about 492.5. The acetyl cap improves stability and helps the peptide penetrate the skin barrier.
Under-eye puffiness is largely a matter of fluid accumulating in the skin around the eye, driven by poor lymphatic drainage and leaky capillaries. Acetyl Tetrapeptide-5 is reported to reduce vascular permeability and support drainage, and to inhibit the glycation of skin proteins that contributes to loss of elasticity and eye-bag formation. The combined effect is used to limit fluid build-up and improve the look of the eye area. This is a topical cosmetic effect at low concentrations, not a systemic or medical treatment.
Acetyl Tetrapeptide-5 is water-soluble and is added to leave-on eye products such as serums, gels, and creams. Typical use levels are low, commonly in the range of 0.01% to 0.1% of the finished formula, with efficacy reported at around 0.1%. It is compatible with a wide pH range and easy to incorporate.
The peptide is used at trace levels and is handled as a standard cosmetic raw material. Supplier studies report a reduction in the look of under-eye puffiness over several weeks of use, but any claim on a finished product is the responsibility of the formulator, and finished products should be safety-assessed for their specific formula and use.
We manufacture Acetyl Tetrapeptide-5 by solid-phase synthesis, including the N-terminal acetylation, and supply it from milligram to kilogram scale with a COA, HPLC, and MS report. For related ingredients and the underlying chemistry, see cosmetic peptides, custom peptide synthesis, and peptide modification. This material is supplied for cosmetic formulation and research use and is not a drug.
