| Product Name | Desmopressin |
| Synonyms | DDAVP, dDAVP, 1-deamino-8-D-arginine vasopressin, [deamino-Cys1, D-Arg8]-vasopressin, Minirin |
| CAS Number | 16679-58-6 (free base); acetate salts 62288-83-9 (mono), 16789-98-3 (di) |
| Sequence (3-Letter) | Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH₂ (cyclic Mpa1–Cys6 disulfide) |
| Sequence (1-Letter) | (Mpa)YFQNCPrG-NH₂ (Mpa = 3-mercaptopropionyl; r = D-Arg) |
| Molecular Formula | C₄₆H₆₄N₁₄O₁₂S₂ |
| Molecular Weight | 1069.22 |
| Category | Drug Peptide – Vasopressin (V2) Analog |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white powder |
| Counter Ion | Acetate (supplied as the acetate salt; free base / TFA-free available on request) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg (research quantities to scale-up batches) |
| QC Documentation | COA, HPLC, MS identity (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Desmopressin is a synthetic cyclic nonapeptide and an analog of the natural hormone vasopressin, widely known as DDAVP (CAS 16679-58-6; acetate salts also available). Its sequence is Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2, closed by a disulfide bridge, where the first residue is deaminated and position eight is a D-arginine. We supply it as a white powder for research and pharmaceutical development.
Desmopressin is a selective agonist at the V2 vasopressin receptor in the kidney, where it promotes water reabsorption and concentrates the urine, with little effect on blood pressure because it has low activity at the V1 receptor. It also raises plasma levels of von Willebrand factor and factor VIII, which supports clotting. The two structural changes from vasopressin make it longer-acting and more selective.
Clinically, desmopressin is used in central diabetes insipidus, in bedwetting and night-time urine problems, and to support clotting in mild haemophilia A and von Willebrand disease. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Desmopressin with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation. Additional documentation for API and regulatory work is available on request, and salt form and purity can be set to your specification.
Yes. We manufacture Desmopressin in-house and supply from research quantities up to scale-up batches. Contact us with your required purity, salt form, and quantity for a quote.
Desmopressin is a synthetic cyclic nonapeptide and an analog of the natural hormone vasopressin (antidiuretic hormone). It is widely known as DDAVP and is valued for its strong, selective antidiuretic action. We supply it as a raw material for research and pharmaceutical development.
Desmopressin is a nine-residue peptide with the sequence Mpa-Tyr-Phe-Gln-Asn-Cys-Pro-D-Arg-Gly-NH2, closed by a disulfide bridge between the first and sixth residues. It differs from natural vasopressin in two ways: the N-terminal amino group is removed (the deaminated residue, Mpa) and position eight carries a D-arginine instead of L-arginine; both changes make it more stable and more selective. Its free-base CAS number is 16679-58-6 (acetate salts 62288-83-9 and 16789-98-3), its molecular formula is C46H64N14O12S2, and its molecular weight is about 1069.
Desmopressin is a selective agonist at the V2 vasopressin receptor, found mainly in the kidney. Acting there, it increases water reabsorption and concentrates the urine. Because it has only weak activity at the V1 receptor that controls blood vessels, it does this with little effect on blood pressure, unlike natural vasopressin. Desmopressin also raises circulating von Willebrand factor and factor VIII, which is why it is also studied in the setting of clotting.
Desmopressin is used clinically in central diabetes insipidus, in bedwetting and night-time urine problems, and to support clotting in mild haemophilia A and von Willebrand disease. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any therapeutic use is subject to applicable regulatory approval.
We supply Desmopressin with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with further documentation available to support active pharmaceutical ingredient and regulatory work. Purity, salt form, and counter-ion can be set to your specification for use as a reference standard or in process development.
We manufacture Desmopressin by solid-phase synthesis, including the deaminated N-terminus, the D-arginine residue, and the disulfide cyclisation, and supply it from research quantities through to scale-up batches. For related capabilities, see drug peptides, custom peptide synthesis, peptide modification, and cyclic peptides. Material is supplied for research and pharmaceutical manufacturing use only.
