| Product Name | Pentapeptide-18 (Leuphasyl) |
| Synonyms | Leuphasyl, [D-Ala²]-Leu-enkephalin, Tyr-D-Ala-Gly-Phe-Leu, H-Tyr-D-Ala-Gly-Phe-Leu-OH |
| CAS Number | 64963-01-5 |
| Sequence (3-Letter) | H-Tyr-D-Ala-Gly-Phe-Leu-OH |
| Sequence (1-Letter) | YaGFL (a = D-Ala) |
| Molecular Formula | C₂₉H₃₉N₅O₇ |
| Molecular Weight | 569.65 |
| Category | Cosmetic Peptide |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (TFA-free available on request) |
| Peptide Content | ≥90% |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg |
| QC Documentation | COA, HPLC, MS (included with every order) |
| Usage | For cosmetic formulation and research use only. Supplied as a raw material; finished-product efficacy and safety claims are the formulator's responsibility. Not a drug; not for direct use without formulation. |
Pentapeptide-18 is a cosmetic anti-wrinkle peptide, also known by the trade name Leuphasyl, with the sequence Tyr-D-Ala-Gly-Phe-Leu (CAS 64963-01-5). It is an enkephalin-like peptide, designed from the natural neuropeptide leucine-enkephalin with a D-alanine substitution that makes it more stable. It is supplied as a white powder for skincare and research.
It is used in anti-aging products to soften the look of expression lines, such as forehead lines and lines around the eyes. Suppliers describe it as relaxing the signal that drives the contraction of expression muscles. Any efficacy claim on a finished product is the formulator's responsibility.
Expression lines form when facial muscles contract repeatedly. Pentapeptide-18 is an enkephalin-like peptide that couples to enkephalin receptors on the nerve cells near these muscles, where it is reported to modulate calcium and the release of acetylcholine, the signal that tells the muscle to contract. Reducing that signal is the rationale for its smoothing effect on the look of expression lines. This is a cosmetic effect on the appearance of skin.
Yes. Pentapeptide-18 is water-soluble and is often paired with Acetyl Hexapeptide-8 (Argireline), since the two work on the expression-line pathway in different ways. It is added to leave-on serums, creams, and gels at low levels. We can advise on use levels for your product.
Yes. We manufacture Pentapeptide-18 in-house and supply from milligrams to kilograms, with COA, HPLC, and MS included. Contact us with your required purity and quantity for a quote.
Pentapeptide-18 is a synthetic peptide used in anti-aging skincare to soften the look of expression lines on the forehead and around the eyes. It is sold under the trade name Leuphasyl and belongs to the group of so-called neuropeptides that work on the signal behind facial muscle contraction.
It is a five-amino-acid peptide with the sequence Tyr-D-Ala-Gly-Phe-Leu. The design is based on leucine-enkephalin, a natural neuropeptide, with a D-alanine in the second position in place of the natural glycine; this single change makes the peptide far more resistant to breakdown by skin enzymes. Its CAS number is 64963-01-5, its molecular formula is C29H39N5O7, and its molecular weight is about 569.65.
Expression lines build up where facial muscles contract again and again. Pentapeptide-18 is an enkephalin-like peptide that couples to enkephalin receptors on the nerve cells near these muscles. There it is reported to modulate calcium and the release of acetylcholine, the chemical signal that tells the muscle to contract. Softening that signal is the rationale for using it to relax and smooth the look of expression lines. The effect is on the appearance of the skin.
Pentapeptide-18 is water-soluble and is added at low levels to leave-on serums, creams, and gels. It is often combined with acetyl peptides such as Acetyl Hexapeptide-8 (Argireline) and Acetyl Octapeptide-3 (see Snap-8), which act on the same expression-line pathway in complementary ways. As with all cosmetic actives, any claim made on the finished product is the responsibility of the formulator.
Pentapeptide-18 is used at trace levels and is handled as a standard cosmetic raw material. Supplier studies report a reduction in the look of expression lines with regular use, but any claim on a finished product is the responsibility of the formulator, and finished products should be safety-assessed for their specific formula and use.
We manufacture Pentapeptide-18 by solid-phase synthesis, including the D-alanine residue that gives it its stability, and supply it from milligram to kilogram scale with a COA, HPLC, and MS report. For related ingredients and the underlying chemistry, see cosmetic peptides, custom peptide synthesis, and peptide modification. This material is supplied for cosmetic formulation and research use and is not a drug.
