| Product Name | Plecanatide |
| Synonyms | SP-304; (3-Glutamic acid)human uroguanylin; uroguanylin analogue; Plecanatide Impurity (catalogue name) |
| CAS Number | 467426-54-6 (free base) |
| Sequence (3-Letter) | H-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH |
| Sequence (1-Letter) | NDECELCVNVACTGCL (16 residues; free-acid C-terminus) |
| Disulfide Bonds | Cys4–Cys12 and Cys7–Cys15 (bis-disulfide) |
| Molecular Formula | C₆₅H₁₀₄N₁₈O₂₆S₄ |
| Molecular Weight | 1681.9 |
| Category | Drug Peptide Impurity / Reference Standard – plecanatide (GC-C agonist, uroguanylin analogue) |
| Purity | ≥98% (by HPLC); reference-standard and pharmaceutical-grade specifications available |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (per specification) |
| Disulfide Bonds | Cys4–Cys12 and Cys7–Cys15 (bis-disulfide) |
| Water Content | Per specification (Karl Fischer) |
| Related Substances | Characterised per specification; named impurity / related-substance reference standards available, including disulfide-isomer forms |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg quantities (reference-standard and research); larger scale on enquiry |
| QC Documentation | COA, HPLC, MS identity; extended characterisation (related substances, peptide content) on request |
| Usage | For research and pharmaceutical analytical / quality-control use only, including as a reference standard for identity and related-substance testing. Not for human or veterinary use; not for sale to patients or individuals. Customers are responsible for regulatory and intellectual-property compliance in their territory. |
Plecanatide is a sixteen-residue cyclic peptide and an analogue of the natural gut hormone uroguanylin, with CAS 467426-54-6 and the molecular formula C65H104N18O26S4 in its free-acid form. It carries two internal disulfide bonds, linking Cys4 to Cys12 and Cys7 to Cys15 within the folded ring, which are essential for its shape and activity. We make it in-house and supply it as a synthetic lyophilized powder for research and analytical use, including as a reference standard.
Analytical and quality-control work needs a well-characterised reference standard of the active peptide to confirm identity, calibrate assays, and run system-suitability and related-substance tests. Plecanatide reference material is used this way in the control of plecanatide drug substances and products. We supply it with full identity and purity data so it can serve as the parent reference alongside named impurity standards.
Plecanatide is a folded peptide with four cysteines and two disulfide bonds, so the main quality challenge is correct disulfide pairing, and it can form a defined set of related substances during synthesis and storage. Common ones include disulfide-bond isomers with mispaired cysteines, the reduced open-chain form, deamidation products at the asparagine and glutamine residues, and truncated or oxidised species. These are controlled in pharmacopoeial and in-house methods, and we can prepare named impurity and related-substance reference standards alongside the parent peptide for method development and stability work.
We supply Plecanatide as a synthetic peptide at high HPLC purity with a certificate of analysis, an HPLC chromatogram, and mass-spec identity confirmation. Reference-standard and pharmaceutical-grade specifications are available, including extended characterisation of related substances and disulfide-isomer forms. Salt form, purity, and quantity can be set to your specification.
No. Plecanatide supplied by SynPeptide is a raw material for research and pharmaceutical development, analysis, and manufacturing only. It is not a finished medicine, it is not for human or veterinary use, and it is not sold to patients or individuals for personal use. Any clinical or commercial medicinal use is the responsibility of an appropriately licensed party and is subject to the relevant regulatory approvals.
Plecanatide (CAS 467426-54-6) is a sixteen-residue analogue of the human gut hormone uroguanylin and a guanylate cyclase-C agonist. In a peptide impurity and reference-standard programme it is the parent compound against which related substances are measured, and we supply it as a synthetic peptide for research, analytical, and quality-control use, including as a reference standard. It is not supplied as a finished medicine and not for human use.
Plecanatide has the sequence H-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH (one-letter NDECELCVNVACTGCL) with a free-acid C-terminus. Its sixteen residues fold into a compact structure held by two disulfide bonds, one between Cys4 and Cys12 and one between Cys7 and Cys15. Its molecular formula is C65H104N18O26S4 and its molecular weight is about 1681.9. It is structurally almost identical to human uroguanylin, differing only by a glutamic acid in place of aspartic acid at position 3.
Uroguanylin is a natural peptide made in the gut that helps regulate fluid and salt balance through the guanylate cyclase-C receptor. Plecanatide reproduces this structure with a single change: a glutamic acid at position 3 in place of the aspartic acid found in uroguanylin. This substitution keeps the receptor activity while altering the behaviour of the peptide, and the two disulfide bonds and cysteine framework that uroguanylin needs for activity are preserved. Because the molecules are so close, uroguanylin-type sequences are among the related substances that analytical methods for plecanatide are designed to resolve.
Regulated peptide manufacturing needs reference standards to confirm identity, calibrate assays, and run system-suitability and related-substance tests. As a peptide drug substance with pharmacopoeial monographs, plecanatide is routinely controlled this way. We supply well-characterised plecanatide reference material with full identity and purity data, so it can serve as the parent reference alongside named impurity standards in method development, release testing, and stability studies.
Because plecanatide carries four cysteines and two disulfide bonds, the central analytical challenge is confirming the correct disulfide pairing, and the peptide can form a characteristic set of related substances during synthesis, purification, and storage. Typical ones include disulfide-bond isomers with mispaired cysteines, the reduced open-chain form, deamidation products at the asparagine and glutamine residues, acetylated, truncated, and oxidised species, and closely related uroguanylin-type sequences. These are the species that pharmacopoeial and in-house related-substance methods are designed to separate and limit, and we can prepare named impurity and related-substance reference standards to order.
Plecanatide is an agonist of guanylate cyclase-C, a receptor on the luminal surface of the intestinal lining. By binding this receptor it raises intracellular cyclic GMP, which increases secretion of chloride and bicarbonate and the movement of fluid into the gut, the basis for its research and clinical use in chronic constipation. This is provided as factual background; the material we supply is for research and analytical use, not for human or veterinary use, not for sale to patients, and carries no health or therapeutic claims.
Store the lyophilized peptide at -20°C, kept dry and protected from light. Because plecanatide relies on two correctly paired disulfide bonds, avoid reducing conditions and strong oxidants that could open or scramble the bonds, and note that the asparagine and glutamine residues make controlled handling important to limit deamidation. The peptide is best reconstituted in a suitable aqueous buffer; aliquot stock solutions to avoid repeated freeze-thaw, and follow the certificate of analysis for lot-specific peptide and water content.
We make Plecanatide and its related-substance reference standards by solid-phase synthesis with controlled, regioselective disulfide formation, and release them with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with grade and salt form set to your specification. Impurity and related-substance reference standards are prepared through our peptide modification and custom peptide synthesis services, and this product sits in our drug peptide impurities reference-standard range. Material is supplied for research and pharmaceutical analytical or manufacturing use only; customers are responsible for the regulatory and intellectual-property requirements that apply in their territory.
