| Product Name | Acetyl Octapeptide-3 (Snap-8) |
| Synonyms | Snap-8, Acetyl Glutamyl Heptapeptide-3, Ac-EEMQRRAD-NH₂, N-acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp |
| CAS Number | 868844-74-0 |
| Sequence (3-Letter) | Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH₂ |
| Sequence (1-Letter) | Ac-EEMQRRAD-NH₂ |
| Molecular Formula | C₄₁H₇₀N₁₆O₁₆S |
| Molecular Weight | 1075.16 |
| Category | Cosmetic Peptide |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white powder |
| Counter Ion | Acetate (TFA-free available on request) |
| Peptide Content | ≥90% |
| Solubility | Soluble in water and DMSO |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg |
| QC Documentation | COA, HPLC, MS (included with every order) |
| Usage | For cosmetic formulation and research use only. Supplied as a raw material; finished-product efficacy and safety claims are the formulator's responsibility. Not a drug; not for direct use without formulation. |
Snap-8 is the cosmetic peptide Acetyl Octapeptide-3, sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (CAS 868844-74-0). It is an eight-amino-acid anti-wrinkle peptide developed as an extended version of the well-known hexapeptide Argireline. It is supplied as a white powder for skincare and research.
Snap-8 is used as an anti-wrinkle ingredient aimed at expression lines, the dynamic wrinkles on the forehead and around the eyes. It is formulated into anti-aging serums and creams to help soften the look of these lines. Any efficacy claim on a finished product is the formulator's responsibility.
Snap-8 (Acetyl Octapeptide-3) is an elongated analog of Argireline (Acetyl Hexapeptide-8): it keeps the same core sequence and adds two residues, alanine and aspartic acid, which extend the part of the SNAP-25 protein it mimics. Both target the same expression-line mechanism, and suppliers position Snap-8 as a more active version.
Snap-8 is water-soluble and is added to leave-on products such as serums, creams, and eye products, often at a few percent of the finished formula. It pairs well with other peptides and humectants. We can advise on use levels for your product.
Yes. We manufacture Snap-8 in-house and supply from milligrams to kilograms, with COA, HPLC, and MS included. Contact us with your required purity and quantity for a quote.
Snap-8 is the trade name for Acetyl Octapeptide-3, a synthetic peptide used in anti-aging skincare to soften the look of expression lines. It was developed as an extended version of the well-known anti-wrinkle peptide Argireline, and it is one of the more widely used peptides aimed at dynamic wrinkles on the forehead and around the eyes.
Snap-8 is an eight-amino-acid peptide with the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, capped with an acetyl group on the N-terminus. Its CAS number is 868844-74-0, its molecular formula is C41H70N16O16S, and its molecular weight is about 1075. In ingredient lists it appears under its INCI name, Acetyl Octapeptide-3.
Snap-8 is designed to mimic part of SNAP-25, a protein in the SNARE complex that nerve cells use to release neurotransmitters at the neuromuscular junction. By competing with SNAP-25, the peptide is intended to modulate the signaling behind repeated facial-muscle contraction, which over time deepens expression lines. In a topical product this is the rationale for using Snap-8 to soften the look of dynamic wrinkles. It is a topical cosmetic ingredient applied to the skin surface, not a drug, and its effect is on the appearance of the skin.
Snap-8 is an elongated analog of Argireline (Acetyl Hexapeptide-8). It shares the same core sequence and adds two residues, alanine and aspartic acid, extending the stretch of SNAP-25 that it mimics. Suppliers position Snap-8 as more active than the parent hexapeptide, and the two are often compared when formulators choose an expression-line peptide.
Snap-8 is water-soluble and is used in leave-on products such as serums, creams, and eye products, typically at a few percent of the finished formula. It is handled as a standard cosmetic raw material. Supplier studies report a reduction in the look of expression lines with regular use, but any claim on a finished product is the responsibility of the formulator, and finished products should be safety-assessed for their specific formula and use.
We manufacture Snap-8 by solid-phase synthesis, including the N-terminal acetylation and the C-terminal amide, and supply it from milligram to kilogram scale with a COA, HPLC, and MS report. For related ingredients and the underlying chemistry, see cosmetic peptides, custom peptide synthesis, and peptide modification. This material is supplied for cosmetic formulation and research use and is not a drug.
