| Product Name | Thymalfasin |
| Synonyms | Thymosin alpha-1, Tα1, Zadaxin |
| CAS Number | 69440-99-9 (thymalfasin); thymosin alpha-1 also listed as 62304-98-7 |
| Sequence (3-Letter) | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (N-terminal acetylation) |
| Sequence (1-Letter) | Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN |
| Molecular Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Weight | 3108.3 |
| Category | Drug Peptide – Thymic Immunomodulatory Peptide |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (salt form per specification) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg (research quantities to scale-up batches) |
| QC Documentation | COA, HPLC, MS identity (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Thymalfasin is a synthetic 28-amino-acid immunomodulatory peptide, the pharmaceutical name for thymosin alpha-1, marketed as Zadaxin (CAS 69440-99-9; also listed as 62304-98-7). Its sequence is Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, an acetylated peptide based on the N-terminal part of the natural protein prothymosin alpha, with no cysteines and no disulfide bonds. We supply it as a white powder for research and pharmaceutical development.
Thymalfasin is an immune modulator that strengthens the Th1 arm of the immune response. Research describes it acting through toll-like receptors on dendritic cells to help those cells mature and release signalling molecules, and supporting the development and activity of T cells and natural killer cells. The overall effect is to help tune the immune response rather than simply switch it on.
Clinically, thymalfasin is used in chronic viral hepatitis and as an immune-supporting agent in several other settings, and it is approved as Zadaxin in a number of countries. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Thymalfasin with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation. Additional documentation for API and regulatory work is available on request, and salt form and purity can be set to your specification.
Yes. We manufacture Thymalfasin in-house and supply from research quantities up to scale-up batches. Contact us with your required purity, salt form, and quantity for a quote.
Thymalfasin is a synthetic 28-amino-acid immunomodulatory peptide and is the pharmaceutical name for thymosin alpha-1, a thymic peptide marketed as Zadaxin. We supply it as a raw material for research and pharmaceutical development.
Thymalfasin is the synthetic form of thymosin alpha-1, a 28-residue peptide corresponding to the N-terminal part of the natural protein prothymosin alpha. Its sequence is Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, with an acetyl group on the N-terminal serine and no other modifications. It contains no cysteine residues and no disulfide bonds, so it is a simple linear chain. Its CAS number is 69440-99-9 (thymosin alpha-1 is also listed as 62304-98-7), its molecular formula is C129H215N33O55, and its molecular weight is about 3108.
Thymalfasin is an immunomodulator rather than a simple stimulant: it helps tune the immune response, with a bias toward the Th1 pathway. Published research describes it signalling through toll-like receptors on dendritic cells, helping those cells mature and release cytokines, and supporting the differentiation and activity of T cells and natural killer cells. Through these effects it can strengthen cell-mediated immunity.
Thymalfasin is used clinically in chronic viral hepatitis and as an immune-supporting agent in a range of other settings, and it is approved under the brand name Zadaxin in more than thirty countries. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any therapeutic use is subject to applicable regulatory approval.
We supply Thymalfasin with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with further documentation available to support active pharmaceutical ingredient and regulatory work. Purity, salt form, and counter-ion can be set to your specification for use as a reference standard or in process development.
We manufacture Thymalfasin by solid-phase synthesis, including the N-terminal acetylation, and supply it from research quantities through to scale-up batches. For related capabilities, see drug peptides, custom peptide synthesis, peptide modification, and large-scale peptide synthesis. Material is supplied for research and pharmaceutical manufacturing use only.
