| Product Name | Thymosin Alpha-1 |
| Synonyms | Tα1, Thymosin α1, Thymalfasin, Zadaxin |
| CAS Number | 62304-98-7 (thymosin alpha-1); pharmaceutical form thymalfasin also listed as 69440-99-9 |
| Sequence (3-Letter) | Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (N-terminal acetylation) |
| Sequence (1-Letter) | Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN |
| Molecular Formula | C₁₂₉H₂₁₅N₃₃O₅₅ |
| Molecular Weight | 3108.3 |
| Category | Drug Peptide – Thymic Immunomodulatory Peptide |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (salt form per specification) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg (research quantities to scale-up batches) |
| QC Documentation | COA, HPLC, MS identity (additional API/regulatory and reference-standard documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Thymosin alpha-1, often shortened to T-alpha-one, is a natural twenty-eight-amino-acid peptide first isolated from the thymus gland (CAS 62304-98-7). Its sequence is Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, an acetylated chain that forms the N-terminal part of the larger protein prothymosin alpha, with no cysteines and no disulfide bonds. It is the peptide that the pharmaceutical thymalfasin is based on. We supply it as a white powder for research and pharmaceutical development.
They are the same molecule. Thymosin alpha-one is the name used for the thymic peptide itself and is commonly listed under CAS 62304-98-7, while thymalfasin is the pharmaceutical name for the synthetic form, often listed under CAS 69440-99-9 and sold as Zadaxin. We list them as separate items so you can order against the registry you need; the underlying peptide and sequence are identical. See also our thymalfasin page.
Thymosin alpha-one is an immunomodulator. In research it has been shown to favour the Th-one side of the immune response, to signal through toll-like receptors on dendritic cells, and to support the maturation and activity of T cells and natural killer cells. It is widely used as a research peptide and as a reference standard for the corresponding drug substance.
We supply Thymosin Alpha-1 with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation. Additional documentation for API and regulatory work is available on request, and salt form and purity can be set to your specification, including reference-standard grade.
Yes. We manufacture Thymosin Alpha-1 in-house and supply from research quantities up to scale-up batches. Contact us with your required purity, salt form, and quantity for a quote.
Thymosin alpha-1 (T-alpha-one) is a natural twenty-eight-amino-acid thymic peptide and a well-studied immunomodulator. It is the peptide on which the pharmaceutical thymalfasin is based, and we supply it as a raw material and reference standard for research and pharmaceutical development.
Thymosin alpha-1 is a twenty-eight-residue peptide, Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN, that corresponds to the N-terminal part of the natural protein prothymosin alpha. It was first isolated from thymus tissue and carries an acetyl group on its N-terminal serine, with no other modifications, no cysteine residues, and no disulfide bonds, giving it a simple linear structure. Its CAS number is 62304-98-7, its molecular formula is C129H215N33O55, and its molecular weight is about 3108.
Thymosin alpha-1 and thymalfasin are the same peptide. The name thymosin alpha-1 is generally used for the thymic peptide itself, under CAS 62304-98-7, while thymalfasin is the pharmaceutical name for the synthetic form, under CAS 69440-99-9 and the brand name Zadaxin. We keep them as separate catalogue entries so that customers can order against whichever registry number their documentation requires, while the sequence and structure are identical.
Thymosin alpha-1 acts as an immunomodulator that tunes the immune response rather than simply driving it. Published research describes it favouring the Th-one response, signalling through toll-like receptors on dendritic cells to help those cells mature, and supporting the differentiation and activity of T cells and natural killer cells. Because of this profile it is widely used as a research peptide. This information is provided as scientific background only; the material we supply is for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients.
We supply Thymosin Alpha-1 with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, and can provide it at reference-standard grade for comparison against the corresponding drug substance. Further documentation to support active pharmaceutical ingredient and regulatory work is available on request, and purity and salt form can be set to your specification.
We manufacture Thymosin Alpha-1 by solid-phase synthesis, including the N-terminal acetylation, and supply it from research quantities through to scale-up batches. For related capabilities, see drug peptides, custom peptide synthesis, and peptide modification. Material is supplied for research and pharmaceutical manufacturing use only.
