| Product Name | Vapreotide Acetate |
| Synonyms | Vapreotide, RC-160, Sanvar, Octastatin, BMY-41606 |
| CAS Number | 103222-11-3 (vapreotide); acetate salt also 849479-74-9 |
| Sequence (3-Letter) | H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH₂ (cyclic Cys2–Cys7 disulfide) |
| Sequence (1-Letter) | FCYWKVCW-NH₂ (disulfide Cys2–Cys7; D-Phe1, D-Trp4) |
| Molecular Formula | C₅₇H₇₀N₁₂O₉S₂ (free base) |
| Molecular Weight | 1131.4 (free base) |
| Category | Drug Peptide – Somatostatin Analog (SSTR Agonist) |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white powder |
| Counter Ion | Acetate |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg (research quantities to scale-up batches) |
| QC Documentation | COA, HPLC, MS identity, disulfide-connectivity confirmation (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Vapreotide is a synthetic cyclic octapeptide and a somatostatin analog, also known as RC-160 and by the brand name Sanvar (CAS 103222-11-3; acetate salt 849479-74-9). It is supplied here as the acetate salt. Its sequence is FCYWKVCW-NH2, a ring closed by a disulfide bond between two cysteines, with D-amino acids and a C-terminal amide that make it more stable than natural somatostatin. We supply it as a white powder for research and pharmaceutical development.
Vapreotide mimics the natural hormone somatostatin. It binds somatostatin receptors and switches off the release of several hormones and digestive secretions, and it reduces blood flow in the vessels supplying the gut. This last effect lowers pressure in the veins around the liver, which is the basis of its use in bleeding.
Clinically, vapreotide is used mainly to help control acute bleeding from swollen veins in the gullet in people with liver cirrhosis, and for certain types of severe diarrhea. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Vapreotide Acetate with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation, and we can confirm the disulfide connectivity. Additional documentation for API and regulatory work is available on request, and purity can be set to your specification.
Yes. We manufacture Vapreotide Acetate in-house and supply from research quantities up to scale-up batches. As a cyclic peptide with a disulfide bond and D-amino acids it is a demanding synthesis, and we can discuss the right approach for your scale. Contact us with your required purity and quantity for a quote.
Vapreotide is a synthetic cyclic octapeptide and a somatostatin analog, also known as RC-160 and under the brand name Sanvar. It is supplied here as the acetate salt as a raw material for research and pharmaceutical development.
Vapreotide is an eight-residue cyclic peptide, FCYWKVCW-NH2, in which a disulfide bond between Cys2 and Cys7 closes the ring. It carries two D-amino acids and a C-terminal amide, which make it more resistant to breakdown and longer-acting than natural somatostatin. It is supplied as the acetate salt. Its CAS number is 103222-11-3 (acetate salt 849479-74-9), its free-base molecular formula is C57H70N12O9S2, and its free-base molecular weight is about 1131.
Vapreotide mimics the natural hormone somatostatin. It binds somatostatin receptors, with a preference for certain subtypes, and suppresses the release of several hormones and of digestive secretions. It also reduces blood flow through the vessels that supply the gut, which lowers pressure in the portal circulation around the liver. Like the related somatostatin analog octreotide, it shares the disulfide-bridged ring that is central to this class.
Vapreotide is used clinically mainly to help control acute bleeding from oesophageal varices in people with liver cirrhosis, where lowering portal pressure is the aim, and for certain forms of severe diarrhea. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any therapeutic use is subject to applicable regulatory approval.
As a cyclic peptide that has to form its disulfide ring correctly, vapreotide calls for careful synthesis and quality control. We supply it with a certificate of analysis, HPLC purity data, mass-spectrometry identity confirmation, and confirmation of disulfide connectivity, with further documentation available to support active pharmaceutical ingredient and regulatory work, and purity set to your specification.
We manufacture Vapreotide Acetate by solid-phase synthesis with controlled disulfide formation, and supply it from research quantities through to scale-up batches. For related capabilities, see drug peptides, custom peptide synthesis, and cyclic peptides. Material is supplied for research and pharmaceutical manufacturing use only.
