| Product Name | Ziconotide Acetate |
| Synonyms | Ziconotide, ω-Conotoxin MVIIA, SNX-111, Prialt |
| CAS Number | 107452-89-1 (ziconotide; supplied as the acetate salt) |
| Sequence (3-Letter) | H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH₂ (disulfides Cys1–Cys16, Cys8–Cys20, Cys15–Cys25) |
| Sequence (1-Letter) | CKGKGAKCSRLMYDCCTGSCRSGKC-NH₂ (3 disulfides: 1–16, 8–20, 15–25; ICK motif) |
| Molecular Formula | C₁₀₂H₁₇₂N₃₆O₃₂S₇ (free base) |
| Molecular Weight | 2639.18 (free base) |
| Category | Drug Peptide – N-type Calcium Channel Blocker (Conotoxin) |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (supplied as the acetate salt) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water and saline buffer |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – g (research quantities; larger scale on enquiry) |
| QC Documentation | COA, HPLC, MS identity, disulfide-connectivity confirmation (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Ziconotide Acetate is the acetate salt of ziconotide, a synthetic 25-amino-acid peptide and the synthetic equivalent of omega-conotoxin MVIIA, a toxin from the cone snail Conus magus (CAS 107452-89-1). Its sequence is CKGKGAKCSRLMYDCCTGSCRSGKC-NH2, folded by three disulfide bonds into a rigid cystine-knot, with a C-terminal amide. It is known as a medicine under the brand name Prialt. We supply it as a white powder for research and pharmaceutical development.
Ziconotide is a selective blocker of the N-type voltage-gated calcium channels that sit on the nerve endings carrying pain signals. By blocking these channels it stops calcium from entering the nerve terminal, which prevents the release of the messengers that pass pain signals on. Because it does not act on opioid receptors, it is a non-opioid analgesic. Its three disulfide bonds lock it into a stable, protease-resistant shape.
Clinically, ziconotide is used to treat severe chronic pain, delivered into the spinal fluid for people who have not been helped by other treatments. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Ziconotide Acetate with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation, and we can confirm the disulfide connectivity. Additional documentation for API and regulatory work is available on request, and purity can be set to your specification.
Yes. We manufacture Ziconotide Acetate in-house. With three disulfide bonds it is a demanding synthesis and fold, and we can discuss the right approach and scale for your needs. Contact us with your required purity and quantity for a quote.
Ziconotide Acetate is the acetate salt of ziconotide, a synthetic 25-amino-acid peptide and the synthetic form of omega-conotoxin MVIIA, a component of the venom of the cone snail Conus magus. It is a non-opioid analgesic and is known as a medicine under the brand name Prialt. We supply it as a raw material for research and pharmaceutical development.
Ziconotide is a 25-residue peptide with the sequence CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 and a C-terminal amide. Its six cysteines form three disulfide bonds, Cys1-Cys16, Cys8-Cys20, and Cys15-Cys25, which thread together into an inhibitor cystine-knot, a rigid scaffold that makes the peptide very resistant to breakdown. Its CAS number is 107452-89-1, its molecular formula is C102H172N36O32S7, and its molecular weight is about 2639.
Ziconotide selectively blocks N-type voltage-gated calcium channels (Cav2.2) on the primary pain-sensing nerve terminals in the spinal cord. Normally, calcium entering through these channels triggers the release of neurotransmitters that pass the pain signal to the next neuron. By blocking the channel, ziconotide stops that calcium influx and the release of pain messengers, producing analgesia. Unlike morphine, it works without acting on opioid receptors, so it is a non-opioid analgesic and does not produce opioid tolerance.
Ziconotide is used clinically for severe chronic pain, given directly into the cerebrospinal fluid for people who have not gained relief from, or cannot tolerate, other treatments. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any therapeutic use is subject to applicable regulatory approval.
With three disulfide bonds that must pair in the correct pattern, ziconotide is one of the more demanding peptides to synthesise and fold. We make it by solid-phase synthesis followed by controlled folding, and supply it with a certificate of analysis, HPLC purity data, mass-spectrometry identity confirmation, and confirmation of disulfide connectivity, with further documentation available to support active pharmaceutical ingredient and regulatory work.
We manufacture Ziconotide Acetate to order, including the three-disulfide fold and the C-terminal amide. For related capabilities, see drug peptides, custom peptide synthesis, peptide modification, and cyclic peptides. Material is supplied for research and pharmaceutical manufacturing use only.
