| Product Name | ACTH (1-10), human |
| Synonyms | Adrenocorticotropic Hormone Fragment 1-10, (1-10)-Corticotropin, ACTH (1-10) (human, rat) |
| CAS Number | 2791-05-1 |
| Sequence (3-Letter) | H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-OH |
| Sequence (1-Letter) | SYSMEHFRWG (10 residues) |
| Molecular Formula | C₅₉H₇₈N₁₆O₁₆S |
| Molecular Weight | 1299.4 |
| Category | Drug Peptide – ACTH N-Terminal Fragment (Melanocortin Ligand) |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate or TFA (salt form per specification) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – g (research quantities; larger scale on enquiry) |
| QC Documentation | COA, HPLC, MS identity (additional documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
ACTH (1-10) is a synthetic peptide made of the first ten amino acids of the hormone ACTH (adrenocorticotropic hormone), CAS 2791-05-1. Its sequence is SYSMEHFRWG. Unlike the longer fragment that contains the first twenty-four residues, this short piece does not stimulate the adrenal glands; it is used mainly as a research peptide. We supply it as a white powder for research and pharmaceutical development.
ACTH shares its N-terminal sequence with the melanocyte-stimulating hormones, and this ten-residue piece carries the core that binds melanocortin receptors. On its own it shows only weak activity at those receptors and, at higher concentrations, a faint melanocyte-stimulating effect. It does not drive cortisol release the way the full hormone does, but it has been reported to affect blood pressure and learning behaviour in animal studies.
ACTH (1-10) is used as a research and model peptide, for example in studies of melanocortin receptors, of the behavioural and cardiovascular effects of ACTH fragments, and as a model peptide in membrane and structural work. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply ACTH (1-10) with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation. Additional documentation for API and regulatory work is available on request, and salt form and purity can be set to your specification.
Yes. We manufacture ACTH (1-10) in-house and supply from research quantities up to larger batches. Contact us with your required purity, salt form, and quantity for a quote.
ACTH (1-10) is a synthetic peptide corresponding to the first ten amino acids of adrenocorticotropic hormone (ACTH). It is used mainly as a research and model peptide, and we supply it as a raw material for research and pharmaceutical development.
ACTH (1-10) is a ten-residue peptide, SYSMEHFRWG, identical to the start of the full ACTH hormone. It is a native sequence with no chemical modifications, no D-amino acids, and no disulfide bonds. Notably it lacks the adrenocorticotropic activity of the longer hormone, because the parts of ACTH needed to drive corticosteroid release extend well beyond the first ten residues. Its CAS number is 2791-05-1, its molecular formula is C59H78N16O16S, and its molecular weight is about 1299.
The N-terminal region of ACTH is shared with the melanocyte-stimulating hormones, and this ten-residue fragment contains the core that interacts with melanocortin receptors. By itself it shows only weak activity at these receptors, with a faint melanocyte-stimulating effect at higher concentrations, and it does not stimulate cortisol release. In animal research it has been associated with effects on blood pressure and on avoidance learning.
ACTH (1-10) is a shorter fragment than the diagnostic peptide ACTH (1-24), which carries the first twenty-four residues of ACTH and retains the full corticosteroid-stimulating activity used in adrenal function testing. ACTH (1-10), by contrast, keeps only the melanocortin core and is used as a research and model peptide rather than for adrenal stimulation.
We supply ACTH (1-10) with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with further documentation available to support active pharmaceutical ingredient and regulatory work. Purity and counter-ion can be set to your specification for use as a reference standard or in research.
We manufacture ACTH (1-10) by solid-phase synthesis and supply it from research quantities through to larger batches. For related capabilities, see drug peptides, custom peptide synthesis, and our catalog peptides. Material is supplied for research and pharmaceutical manufacturing use only.
